Kamagra Jelly is a well-known generic version of the immensely popular erectile dysfunction treatment known as Viagra. In fact, Kamagra Jelly contains sildenafil citrate, the exact same formulation as Viagra.
Pharmaceutical researchers initially were developing sildenafil citrate to treat various cardiac maladies, such as hypertension and angina pectoris. In 1998, biochemists Robert F. Furchgott, Louis Ignarro, and Ferid Murad were awarded the Nobel Prize in Medicine for their research regarding nitric oxide’s role in smooth muscle vasodilation. Since erectile dysfunction had some similarities, it triggered the idea for researchers that sildenafil citrate might be an effective treatment modality.
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Researchers found that sildenafil citrate is a phosphodiesterase type 5 (PDE5) inhibitor. When the penis is stimulated, nitric oxide is released into the erectile tissue, thereby activating an enzyme that increases levels of a chemical called cyclic guanosine monophosphate (cGMP), which caused the blood vessels in the penis to dilate and fill the erectile tissue with blood. Another enzyme called phosphodiesterase type 5 (PDE5) breaks down cGMP, inhibiting blood flow into the penis, causing impotence. Sildenafil citrate stops the action of PDE5 which resolves the dysfunction by permitting sexual stimulation to actuate the cGMP mechanism for achieving/maintaining an erection.
Soon thereafter, sildenafil citrate was available to the afflicted in the form as a little blue pill called Viagra. Since Viagra is so expensive around the world, Ajanta Pharma of India has developed Kamagra Jelly as patent claims do not apply there. That is great news for South African consumers who are looking for an affordable therapy for their erectile dysfunction.
Kamagra Oral Jelly usually comes in preparations of 100mg of sildenafil citrate and is available in a variety of flavored gel sachets. The oral jelly is rapidly absorbed in the oral cavity. The onset of action is around 20-40 minutes so it is suggested that the user consume a sachet of Kamagra Oral Jelly approximately 30-45 minutes before sexual activity. The anti-impotence effects of Kamagra Oral Jelly last around four hours, but could be as much as 6 hours.
There are some potential adverse side effects of Kamagra Oral Jelly use. Some users have reported flushing, headache, impaired vision, cyanopsia (seeing with a blue tint), cardiac effects (low blood pressure, arrhythmias, myocardial infarction, stroke, etc.) and sudden hearing loss. Users of Kamagra Oral Jelly who experience a sustained erection greater than four hours should seek immediate medical attention. A prolonged, painful erection greater than 4 hours could cause permanent damage if left untreated.
Kamagra Oral Jelly may also have interactions with other medications. Kamagra Oral Jelly users who take protease inhibitors (and antiretroviral therapy for HIV), erythromycin (antibiotic), or cimetidine (Tagamet), should first consult a medical professional. The concomitant use of Kamagra Oral Jelly and an alpha blocker may lead to severe hypotension (low blood pressure). The same also applies for organic nitrites and nitrates, such as Nitroprusside, nitroglycerin for angina/chest pain, or Amyl Nitrite (colloquially known as Poppers).
There are numerous contraindications for using Kamagra Oral Jelly. Usage is contraindicated for anyone who has a history of heart attack, stroke, liver or renal impairment, low blood pressure, retinal/eye disorders, or cardiovascular conditions.
South African citizens are fortunate as they are able to obtain Kamagra Oral Jelly as an over the counter therapy for erectile dysfunction. It can be procured from a variety of online websites and mail order companies.
Medical Practitioner (General Practice) with postgraduate diplomas in Cape Town. My special interest is erectile dysfunction.
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